cryptic storyline open to multiple interpretations Cast * Jake Gyllenhaal as Donald J. "Donnie" Darko * Jena Malone as Gretchen Ross * Mary McDonnell as Rose Darko * Holmes Osborne as Eddie Darko * Maggie Gyllenhaal as Elizabeth Darko * Daveigh Chase as Samantha Darko * Patrick Swayze as Jim Cunningham * Drew Barrymore as Karen Pomeroy * Noah Wyle as Kenneth Monnitoff * Beth Grant as Kitty Farmer * Katharine Ross as Dr. Lillian Thurman * Patience Cleveland as Roberta Sparrow (aka Grandma Death ...
